2 research outputs found
Π€Π°ΡΠΌΠ°ΠΊΠΎΠΊΠΈΠ½Π΅ΡΠΈΠΊΠ° ΠΊΠ°Π»ΠΈΠ΅Π²ΠΎΠΉ ΡΠΎΠ»ΠΈ Π΄ΠΈΠΊΠ»ΠΎΡΠ΅Π½Π°ΠΊΠ° ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΈΠ΅ΠΌΠ° ΡΠ°ΡΠ΅ ΠΈ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ
There is a host of pharmaceutical formulations of diclofenac, which ensures that it can be used orally, rectally, intrarectally, or topically. Objective - to comparatively analyze the pharmacokinetic parameters and time course of changes in the serum concentration of diclofenac potassium after oral administration in a dose of 50 mg as sachets or sugar-coated tablets.
Results. There is evidence that patients tolerate both its sachets and tablets equally well, as confirmed by subjective and objective observations. There are neither marked side effects nor considerable changes in laboratory tests and in the values of vital functions. Diclofenac potassium as early-action tablets (50 and 100 mg) exerts a very good analgesic effect in treating migraine since the plasma concentration of the drug peaks on an average of an hour of administration (range 0,33-2 hours) and the analgesic effect developed following 60-90 min. Conclusion. By comparing the rate of absorption, it may be concluded that diclofenac potassium as sachets will produce a much rapider analgesic effect. Thus, the high solubility of diclofenac potassium and its very good absorbability (as sachets in particular) make the drug a superior analgesic that has a rapid analgesic activity.Π‘ΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²ΠΎ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΠΌ Π΄ΠΈΠΊΠ»ΠΎΡΠ΅Π½Π°ΠΊΠ°, Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ ΡΠ΅ΠΌΡ Π΅Π³ΠΎ ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ, ΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎ, Π²Π½ΡΡΡΠΈΠΌΡΡΠ΅ΡΠ½ΠΎ ΠΈΠ»ΠΈ ΠΌΠ΅ΡΡΠ½ΠΎ.
Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ - ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠ°ΡΠΌΠ°ΠΊΠΎΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π²ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΊΠ°Π»ΠΈΠ΅Π²ΠΎΠΉ ΡΠΎΠ»ΠΈ Π΄ΠΈΠΊΠ»ΠΎΡΠ΅Π½Π°ΠΊΠ° ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΈΠ΅ΠΌΠ° Π² Π΄ΠΎΠ·Π΅ 50 ΠΌΠ³ Π² ΡΠΎΡΠΌΠ΅ ΡΠ°ΡΠ΅ ΠΈΠ»ΠΈ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ, ΠΏΠΎΠΊΡΡΡΡΡ
ΡΠ°Ρ
Π°ΡΠ½ΠΎΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΎΠΉ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΈ ΡΠ°ΡΠ΅, ΠΈ ΡΠ°Π±Π»Π΅ΡΠΊΠΈ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠ»ΠΈ ΠΎΠ΄ΠΈΠ½Π°ΠΊΠΎΠ²ΠΎ Ρ
ΠΎΡΠΎΡΠΎ, ΠΎ ΡΠ΅ΠΌ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°Π»ΠΈ ΡΡΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΈ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ. ΠΡΡΠ°ΠΆΠ΅Π½Π½ΡΠ΅ ΠΏΠΎΠ±ΠΎΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΠΎΡΡΡΡΡΡΠ²ΠΎΠ²Π°Π»ΠΈ, Π° Π² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
Π°Π½Π°Π»ΠΈΠ·Π°Ρ
ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡ
ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎ Π²Π°ΠΆΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ Π½Π΅ ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΎΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ. ΠΠ°Π»ΠΈΠ΅Π²Π°Ρ ΡΠΎΠ»Ρ Π΄ΠΈΠΊΠ»ΠΎΡΠ΅Π½Π°ΠΊΠ° Π² ΡΠΎΡΠΌΠ΅ ΡΠ°Π±Π»Π΅ΡΠΎΠΊ Ρ Π½Π΅ΠΌΠ΅Π΄Π»Π΅Π½Π½ΡΠΌ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ΠΌ (50 ΠΈ 100ΠΌΠ³) ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ ΠΎΡΠ΅Π½Ρ Ρ
ΠΎΡΠΎΡΠ΅Π΅ ΠΎΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°ΡΡΠ΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΌΠΈΠ³ΡΠ΅Π½ΠΈ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ Π΄ΠΎΡΡΠΈΠ³Π°Π»Π° ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ ΡΠ΅ΡΠ΅Π· 1 Ρ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΈΠ΅ΠΌΠ° (ΡΠ΅ΡΠ΅Π· 0,33-2 Ρ), Π° Π°Π½Π°Π»ΡΠ³Π΅Π·ΠΈΡΡΡΡΠΈΠΉ ΡΡΡΠ΅ΠΊΡ ΡΠ°Π·Π²ΠΈΠ²Π°Π»ΡΡ ΡΠ΅ΡΠ΅Π· 60-90ΠΌΠΈΠ½. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π‘ΡΠ°Π²Π½ΠΈΠ²Π°Ρ ΡΠΊΠΎΡΠΎΡΡΡ Π²ΡΠ°ΡΡΠ²Π°Π½ΠΈΡ, ΠΌΠΎΠΆΠ½ΠΎ Π·Π°ΠΊΠ»ΡΡΠΈΡΡ, ΡΡΠΎ Π΄ΠΈΠΊΠ»ΠΎΡΠ΅Π½Π°ΠΊ ΠΊΠ°Π»ΠΈΡ Π² ΡΠΎΡΠΌΠ΅ ΡΠ°ΡΠ΅ Π±ΡΠ΄Π΅Ρ Π΄Π°Π²Π°ΡΡ Π³ΠΎΡΠ°Π·Π΄ΠΎ Π±ΠΎΠ»Π΅Π΅ Π±ΡΡΡΡΡΠΉ ΠΎΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°ΡΡΠΈΠΉ ΡΡΡΠ΅ΠΊΡ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π²ΡΡΠΎΠΊΠ°Ρ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠΎΡΡΡ ΠΊΠ°Π»ΠΈΠ΅Π²ΠΎΠΉ ΡΠΎΠ»ΠΈ Π΄ΠΈΠΊΠ»ΠΎΡΠ΅Π½Π°ΠΊΠ° ΠΈ ΠΎΡΠ΅Π½Ρ Ρ
ΠΎΡΠΎΡΠ°Ρ Π²ΡΠ°ΡΡΠ²Π°Π΅ΠΌΠΎΡΡΡ (ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΡΠ°ΡΠ΅) Π΄Π΅Π»Π°ΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΏΡΠ΅Π²ΠΎΡΡ
ΠΎΠ΄Π½ΡΠΌ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΠΊΠΎΠΌ, ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΠΈΠΌ Π±ΡΡΡΡΠΎΠ΅ ΠΎΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°ΡΡΠ΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅
Pharmacokinetics of diclofenac potassium after oral administration of sachets and tablets
There is a host of pharmaceutical formulations of diclofenac, which ensures that it can be used orally, rectally, intrarectally, or topically. Objective - to comparatively analyze the pharmacokinetic parameters and time course of changes in the serum concentration of diclofenac potassium after oral administration in a dose of 50 mg as sachets or sugar-coated tablets.
Results. There is evidence that patients tolerate both its sachets and tablets equally well, as confirmed by subjective and objective observations. There are neither marked side effects nor considerable changes in laboratory tests and in the values of vital functions. Diclofenac potassium as early-action tablets (50 and 100 mg) exerts a very good analgesic effect in treating migraine since the plasma concentration of the drug peaks on an average of an hour of administration (range 0,33-2 hours) and the analgesic effect developed following 60-90 min. Conclusion. By comparing the rate of absorption, it may be concluded that diclofenac potassium as sachets will produce a much rapider analgesic effect. Thus, the high solubility of diclofenac potassium and its very good absorbability (as sachets in particular) make the drug a superior analgesic that has a rapid analgesic activity